Precise control of movement kinematics by optogenetic inhibition of purkinje cell activity

• Main Authors: Heiney, Shane A., Kim, Jinsook, Augustine, George J., Medina, Javier F.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/103883; http://hdl.handle.net/10220/19334
• Institution: Nanyang Technological University

Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking.Weused an optogenetic approach in awake mice to show for the first time that tr...