Combining single-molecule manipulation and peptide nucleic acid binding studies for unraveling how RNA structures regulate ribosomal frameshifting and alternative splicing

• Main Author: Yang, Lixia
• Other Authors: Chen Gang
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104424; http://hdl.handle.net/10220/48612
• Institution: Nanyang Technological University

RNA structures are involved in regulating many biological activities such as programmed ribosomal frameshifting and pre-mRNA alternative splicing. Studying the structural features, mechanical stabilities, unfolding and folding dynamics of native RNAs and their mutants, as well as the interaction wit...