Overexpression of CDC42SE1 in A431 cells reduced cell proliferation by inhibiting the Akt pathway

• Main Authors: Kalailingam, Pazhanichamy, Tan, Hui Bing, Pan, Jiun Yit, Tan, Suat Hoon, Thanabalu, Thirumaran
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: CDC42; Skin Cancer; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104785; http://hdl.handle.net/10220/48621
• Institution: Nanyang Technological University

Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of C...