Differences in meiotic recombination rates in childhood acute lymphoblastic leukemia at an MHC class II hotspot close to disease associated haplotypes

• Main Authors: Thompson, Pamela, Urayama, Kevin, Zheng, Jie, Yang, Peng, Ford, Matt, Buffler, Patricia, Chokkalingam, Anand, Lightfoot, Tracy, Taylor, Malcolm
• 其他作者: Galardy, Paul J.
• 格式: Article
• 語言: English
• 出版: 2014
• 主題: DRNTU::Science::Biological sciences::Human anatomy and physiology
• 在線閱讀: https://hdl.handle.net/10356/104863; http://hdl.handle.net/10220/20321
• 機構: Nanyang Technological University

Childhood Acute Lymphoblastic Leukemia (ALL) is a malignant lymphoid disease of which B-cell precursor- (BCP) and T-cell- (T) ALL are subtypes. The role of alleles encoded by major histocompatibility loci (MHC) have been examined in a number of previous studies and results indicating weak, multi-all...