Differences in meiotic recombination rates in childhood acute lymphoblastic leukemia at an MHC class II hotspot close to disease associated haplotypes

• Main Authors: Thompson, Pamela, Urayama, Kevin, Zheng, Jie, Yang, Peng, Ford, Matt, Buffler, Patricia, Chokkalingam, Anand, Lightfoot, Tracy, Taylor, Malcolm
• Other Authors: Galardy, Paul J.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: https://hdl.handle.net/10356/104863; http://hdl.handle.net/10220/20321
• Institution: Nanyang Technological University

Childhood Acute Lymphoblastic Leukemia (ALL) is a malignant lymphoid disease of which B-cell precursor- (BCP) and T-cell- (T) ALL are subtypes. The role of alleles encoded by major histocompatibility loci (MHC) have been examined in a number of previous studies and results indicating weak, multi-all...