Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesi...

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Main Authors: Hu, Benhui, Shi, Wenxiong, Wu, Yun-Long, Leow, Wan Ru, Cai, Pingqiang, Li, Shuzhou, Chen, Xiaodong
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Engineering::Materials
Online Access:https://hdl.handle.net/10356/105186
http://hdl.handle.net/10220/20499
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1051862020-06-01T10:21:14Z Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology Hu, Benhui Shi, Wenxiong Wu, Yun-Long Leow, Wan Ru Cai, Pingqiang Li, Shuzhou Chen, Xiaodong School of Materials Science & Engineering DRNTU::Engineering::Materials Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesion and cell–cell adhesion. Decreasing the cell–matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology. 2014-09-10T07:43:24Z 2019-12-06T21:47:16Z 2014-09-10T07:43:24Z 2019-12-06T21:47:16Z 2014 2014 Journal Article Hu, B., Shi, W., Wu, Y.-L., Leow, W. R., Cai, P., Li, S., et al. (2014). Orthogonally Engineering Matrix Topography and Rigidity to Regulate Multicellular Morphology. Advanced Materials, 26(33), 5786-5793. 0935-9648 https://hdl.handle.net/10356/105186 http://hdl.handle.net/10220/20499 10.1002/adma.201402489 en Advanced materials © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Materials
spellingShingle DRNTU::Engineering::Materials
Hu, Benhui
Shi, Wenxiong
Wu, Yun-Long
Leow, Wan Ru
Cai, Pingqiang
Li, Shuzhou
Chen, Xiaodong
Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
description Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesion and cell–cell adhesion. Decreasing the cell–matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.
author2 School of Materials Science & Engineering
author_facet School of Materials Science & Engineering
Hu, Benhui
Shi, Wenxiong
Wu, Yun-Long
Leow, Wan Ru
Cai, Pingqiang
Li, Shuzhou
Chen, Xiaodong
format Article
author Hu, Benhui
Shi, Wenxiong
Wu, Yun-Long
Leow, Wan Ru
Cai, Pingqiang
Li, Shuzhou
Chen, Xiaodong
author_sort Hu, Benhui
title Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
title_short Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
title_full Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
title_fullStr Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
title_full_unstemmed Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
title_sort orthogonally engineering matrix topography and rigidity to regulate multicellular morphology
publishDate 2014
url https://hdl.handle.net/10356/105186
http://hdl.handle.net/10220/20499
_version_ 1681059178679894016

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