Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

• Main Authors: Hu, Benhui, Shi, Wenxiong, Wu, Yun-Long, Leow, Wan Ru, Cai, Pingqiang, Li, Shuzhou, Chen, Xiaodong
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/105186; http://hdl.handle.net/10220/20499
• Institution: Nanyang Technological University

Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesi...