An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

• المؤلفون الرئيسيون: Pestell, Richard George, Zheng, Ze, Nayak, Lalitha, Wang, Wei, Wang, Xiaobo, Cai, Bishuang, Lapping, Stephanie, Ozcan, Lale, Ramakrishnan, Rajasekhar, Jain, Mukesh K., Tabas, Ira, Yurdagul Jr, Arif
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Fibrinolysis; Hepatocyte-Derived tPA; DRNTU::Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/105253; http://hdl.handle.net/10220/48665; http://dx.doi.org/10.1182/blood-2018-07-864843

Tissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and, thereby, prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute local release by vascular cells in response to injury or other stimuli. However, very little i...