An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

• Main Authors: Pestell, Richard George, Zheng, Ze, Nayak, Lalitha, Wang, Wei, Wang, Xiaobo, Cai, Bishuang, Lapping, Stephanie, Ozcan, Lale, Ramakrishnan, Rajasekhar, Jain, Mukesh K., Tabas, Ira, Yurdagul Jr, Arif
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Fibrinolysis; Hepatocyte-Derived tPA; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/105253; http://hdl.handle.net/10220/48665; http://dx.doi.org/10.1182/blood-2018-07-864843
• Institution: Nanyang Technological University

Tissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and, thereby, prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute local release by vascular cells in response to injury or other stimuli. However, very little i...