An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

Tissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and, thereby, prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute local release by vascular cells in response to injury or other stimuli. However, very little i...

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Bibliographic Details
Main Authors: Pestell, Richard George, Zheng, Ze, Nayak, Lalitha, Wang, Wei, Wang, Xiaobo, Cai, Bishuang, Lapping, Stephanie, Ozcan, Lale, Ramakrishnan, Rajasekhar, Jain, Mukesh K., Tabas, Ira, Yurdagul Jr, Arif
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/105253
http://hdl.handle.net/10220/48665
http://dx.doi.org/10.1182/blood-2018-07-864843
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Institution: Nanyang Technological University
Language: English

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