An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1
Tissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and, thereby, prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute local release by vascular cells in response to injury or other stimuli. However, very little i...
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Main Authors: | Pestell, Richard George, Zheng, Ze, Nayak, Lalitha, Wang, Wei, Wang, Xiaobo, Cai, Bishuang, Lapping, Stephanie, Ozcan, Lale, Ramakrishnan, Rajasekhar, Jain, Mukesh K., Tabas, Ira, Yurdagul Jr, Arif |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2019
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/105253 http://hdl.handle.net/10220/48665 http://dx.doi.org/10.1182/blood-2018-07-864843 |
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Institution: | Nanyang Technological University |
Language: | English |
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