1-(2′-Anilinyl)prop-2-yn-1-ol rearrangement for oxindole synthesis

• Main Authors: Kothandaraman, Prasath, Koh, Bing Qin, Limpanuparb, Taweetham, Hirao, Hajime, Chan, Philip Wai Hong
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2013
• 在線閱讀: https://hdl.handle.net/10356/105286; http://hdl.handle.net/10220/16575; http://dx.doi.org/10.1002/chem.201202606

A synthetic method that relies on NIS (N-iodosuccinimide)-mediated cycloisomerization reactions of 1-(2′-anilinyl)prop-2-yn-1-ols to gem-3-(diiodomethyl)indolin-2-ones and 2-(iodomethylene)indolin-3-ones has been developed. The reactions were shown to be chemoselective, with secondary and tertiary a...