Adaptor protein regulation of T-lymphocyte migration
T-lymphocyte migration is central to the adaptive immune response, which is dependent mainly on the integrin LFA-1-mediated signalling. LFA-1 interacts with its ligand ICAM-1 (expressed on endothelium) and this interaction triggers cytoskeletal rearrangement and T-cell motility. Centrosome and Golgi...
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| Other Authors: | |
| Format: | Student Research Poster |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/105641 http://hdl.handle.net/10220/25933 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | T-lymphocyte migration is central to the adaptive immune response, which is dependent mainly on the integrin LFA-1-mediated signalling. LFA-1 interacts with its ligand ICAM-1 (expressed on endothelium) and this interaction triggers cytoskeletal rearrangement and T-cell motility. Centrosome and Golgi localized Protein Kinase N- Associated Protein (CG-NAP) is an adaptor protein and plays a multifunctional role in facilitating signal transduction processes. However, the mechanistic role of CG-NAP in T-lymphocyte migration is not clear. [4th Award] |
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