ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response

• Main Authors: Tan, Eddie Han Pin, Sng, Ming Keat, How, Ivan Shun Bo, Chan, Jeremy Soon Kiat, Chen, Jiapeng, Tan, Chek Kun, Wahli, Walter, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Reactive Oxygen Species; DRNTU::Science::Biological sciences; Colorectal Cancer
• Online Access: https://hdl.handle.net/10356/105743; http://hdl.handle.net/10220/48738
• Institution: Nanyang Technological University

Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evid...