Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans

Background : Insulin resistance and related metabolic disturbances are major risk factors for the higher T2D risk and associated morbidity and mortality amongst South Asians. The contribution of physical activity to the increased prevalence of insulin resistance and related disturbances amongst Sout...

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Main Authors: Afaq, Saima, Kooner, Angad S., Loh, Marie, Kooner, Jaspal S., Chambers, John Campbell
Other Authors: Meyre, David
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/105971
http://hdl.handle.net/10220/48857
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1059712020-11-01T05:10:29Z Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans Afaq, Saima Kooner, Angad S. Loh, Marie Kooner, Jaspal S. Chambers, John Campbell Meyre, David Lee Kong Chian School of Medicine (LKCMedicine) Physical Activity Insulin Resistance DRNTU::Science::Medicine Background : Insulin resistance and related metabolic disturbances are major risk factors for the higher T2D risk and associated morbidity and mortality amongst South Asians. The contribution of physical activity to the increased prevalence of insulin resistance and related disturbances amongst South Asians is unknown. Methods : We recruited 902 South Asian and European men and women, aged 35–85 years from the ongoing LOLIPOP study. Clinical characterisation comprised standardised questionnaire and measurement of height, weight, waist and hip circumference and blood pressure. Fasting bloods were taken for assessment of glucose, insulin, lipids and HbA1c. Physical activity was quantified using a validated accelerometer, Actigraph GT3X+, worn for 7 days. Univariate and multivariate approaches were used to investigate the relationship between ethnicity, physical activity, insulin resistance and related metabolic disturbances. Results : Total physical activity was ~31% (P = 0.01) lower amongst South Asians compared to Europeans (Mean MET.minutes [SD]: 1505.2 [52] vs. 2050.9 [86.6], P<0.001). After adjusting for age and sex, total physical activity had a negative association with HOMA-IR (B [SE]: -0.18 [0.08], P = 0.04) and fasting glucose levels (B[SE]: -0.11 [0.04], P = 0.02). There was no association between physical activity and other glycemic and lipid parameters. Total physical activity per week contributed towards the differences in insulin resistance and associated metabolic disturbances between South Asians and Europeans. Conclusion : Lower levels of physical activity may contribute to the increased insulin resistance in South Asians compared to Europeans. Our results suggest that lifestyle modification through increased physical activity may help to improve glucose metabolism and reduce the burden of excess T2D and related complications amongst South Asians. Published version 2019-06-20T02:46:00Z 2019-12-06T22:01:54Z 2019-06-20T02:46:00Z 2019-12-06T22:01:54Z 2019 Journal Article Afaq, S., Kooner, A. S., Loh, M., Kooner, J. S., & Chambers, J. C. (2019). Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans. PLOS ONE, 14(5), e0216354-. doi:10.1371/journal.pone.0216354 https://hdl.handle.net/10356/105971 http://hdl.handle.net/10220/48857 10.1371/journal.pone.0216354 en PLOS ONE © 2019 Afaq et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 13 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Physical Activity
Insulin Resistance
DRNTU::Science::Medicine
spellingShingle Physical Activity
Insulin Resistance
DRNTU::Science::Medicine
Afaq, Saima
Kooner, Angad S.
Loh, Marie
Kooner, Jaspal S.
Chambers, John Campbell
Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
description Background : Insulin resistance and related metabolic disturbances are major risk factors for the higher T2D risk and associated morbidity and mortality amongst South Asians. The contribution of physical activity to the increased prevalence of insulin resistance and related disturbances amongst South Asians is unknown. Methods : We recruited 902 South Asian and European men and women, aged 35–85 years from the ongoing LOLIPOP study. Clinical characterisation comprised standardised questionnaire and measurement of height, weight, waist and hip circumference and blood pressure. Fasting bloods were taken for assessment of glucose, insulin, lipids and HbA1c. Physical activity was quantified using a validated accelerometer, Actigraph GT3X+, worn for 7 days. Univariate and multivariate approaches were used to investigate the relationship between ethnicity, physical activity, insulin resistance and related metabolic disturbances. Results : Total physical activity was ~31% (P = 0.01) lower amongst South Asians compared to Europeans (Mean MET.minutes [SD]: 1505.2 [52] vs. 2050.9 [86.6], P<0.001). After adjusting for age and sex, total physical activity had a negative association with HOMA-IR (B [SE]: -0.18 [0.08], P = 0.04) and fasting glucose levels (B[SE]: -0.11 [0.04], P = 0.02). There was no association between physical activity and other glycemic and lipid parameters. Total physical activity per week contributed towards the differences in insulin resistance and associated metabolic disturbances between South Asians and Europeans. Conclusion : Lower levels of physical activity may contribute to the increased insulin resistance in South Asians compared to Europeans. Our results suggest that lifestyle modification through increased physical activity may help to improve glucose metabolism and reduce the burden of excess T2D and related complications amongst South Asians.
author2 Meyre, David
author_facet Meyre, David
Afaq, Saima
Kooner, Angad S.
Loh, Marie
Kooner, Jaspal S.
Chambers, John Campbell
format Article
author Afaq, Saima
Kooner, Angad S.
Loh, Marie
Kooner, Jaspal S.
Chambers, John Campbell
author_sort Afaq, Saima
title Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
title_short Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
title_full Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
title_fullStr Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
title_full_unstemmed Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
title_sort contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in south asians compared to europeans
publishDate 2019
url https://hdl.handle.net/10356/105971
http://hdl.handle.net/10220/48857
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