Identification of five structurally unrelated quorum-sensing inhibitors of pseudomonas aeruginosa from a natural-derivative database

• Main Authors: Tan, Sean Yang-Yi, Chua, Song-Lin, Chen, Yicai, Rice, Scott A., Kjelleberg, Staffan, Nielsen, Thomas Eiland, Yang, Liang, Givskov, Michael
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/106210; http://hdl.handle.net/10220/26348
• Institution: Nanyang Technological University

Bacteria communicate by means of small signal molecules in a process termed quorum sensing (QS). QS enables bacteria to organize their activities at the population level, including the coordinated secretion of virulence factors. Certain small-molecule compounds, known as quorum-sensing inhibitors (Q...