Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway

• Main Authors: Ye, Weijian, Chew, Marvin, Hou, Jue, Lai, Fritz, Leopold, Stije J., Loo, Hooi Linn, Ghose, Aniruddha, Dutta, Ashok K., Chen, Qingfeng, Ooi, Eng Eong, White, Nicholas J., Dondorp, Arjen M., Preiser, Peter, Chen, Jianzhu
• Other Authors: Goodier, Martin
• Format: Article
• Language: English
• Published: 2019
• Subjects: NK Cells; Malaria; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106329; http://hdl.handle.net/10220/47420
• Institution: Nanyang Technological University

Natural killer (NK) cells provide the first line of defense against malaria parasite infection. However, the molecular mechanisms through which NK cells are activated by parasites are largely unknown, so is the molecular basis underlying the variation in NK cell responses to malaria infection in the...