Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury

• Main Authors: Chen, Bo, Ng, Gandi, Gao, Yahui, Low, See Wee, Sandanaraj, Edwin, Ramasamy, Boominathan, Sekar, Sakthivel, Bhakoo, Kishore, Soong, Tuck Wah, Nilius, Bernd, Tang, Carol, Robins, Edward G., Goggi, Julian, Liao, Ping
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Stroke; Science::Biological sciences; Reperfusion
• Online Access: https://hdl.handle.net/10356/106391; http://hdl.handle.net/10220/49616
• Institution: Nanyang Technological University

The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel, in particular by direct channel suppression, is lacking. In this study, we used multimodal imaging to assess edema fo...