Development of a ribonuclease containing a G4-specific binding motif for programmable RNA cleavage

We developed a ribonuclease for site-specific targeting and cleavage of single-stranded RNA. The engineered RNase protein was constructed by incorporating two independent functional domains, an RNase HI domain that could cleave the RNA strand in a DNA-RNA hybrid, and a domain of the RHAU protein tha...

Full description

Saved in:
Bibliographic Details
Main Authors: Phan, Anh Tuân, Dang, Dung Thanh
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/106553
http://hdl.handle.net/10220/48945
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English