Development of a ribonuclease containing a G4-specific binding motif for programmable RNA cleavage
We developed a ribonuclease for site-specific targeting and cleavage of single-stranded RNA. The engineered RNase protein was constructed by incorporating two independent functional domains, an RNase HI domain that could cleave the RNA strand in a DNA-RNA hybrid, and a domain of the RHAU protein tha...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/106553 http://hdl.handle.net/10220/48945 |
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| Institution: | Nanyang Technological University |
| Language: | English |