Presynaptic nanodomains : a tale of two synapses

• Main Authors: Wang, Lu-Yang, Augustine, George J.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• Online Access: https://hdl.handle.net/10356/106622; http://hdl.handle.net/10220/25031
• Institution: Nanyang Technological University

Here we summarize the evidence from two “giant” presynaptic terminals—the squid giant synapse and the mammalian calyx of Held—supporting the involvement of nanodomain calcium signals in triggering of neurotransmitter release. At the squid synapse, there are three main lines of experimental evidence...