A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity

• Main Authors: Verma, Pushpa, Augustine, George James, Ammar, Mohamed-Raafet, Tashiro, Ayumu, Cohen, Stephen M
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• Online Access: https://hdl.handle.net/10356/107024; http://hdl.handle.net/10220/25258
• Institution: Nanyang Technological University

Evidence has begun to emerge for microRNAs as regulators of synaptic signaling, specifically acting to control postsynaptic responsiveness during synaptic transmission. In this report, we provide evidence that Drosophila melanogaster miR-1000 acts presynaptically to regulate glutamate release at the...