Presynaptic nanodomains : a tale of two synapses

• Main Authors: Wang, Lu-Yang, Augustine, George J.
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
• 在線閱讀: https://hdl.handle.net/10356/106622; http://hdl.handle.net/10220/25031

Here we summarize the evidence from two “giant” presynaptic terminals—the squid giant synapse and the mammalian calyx of Held—supporting the involvement of nanodomain calcium signals in triggering of neurotransmitter release. At the squid synapse, there are three main lines of experimental evidence...