Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I

• Main Authors: Kwok, Jane, Hui, Kenrie P. Y., Lescar, Julien, Kotaka, Masayo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106637; http://hdl.handle.net/10220/25042
• Institution: Nanyang Technological University

The human innate immune system can detect invasion by microbial pathogens through pattern-recognition receptors that recognize structurally conserved pathogen-associated molecular patterns. Retinoic acid-inducible gene I (RIG-I)-like helicases (RLHs) are one of the two major families of pattern-reco...