MiR‐135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF‐β/BMP signaling

• Main Authors: Bhinge, Akshay, Poschmann, Jeremie, Namboori, Seema C., Tian, Xianfeng, Loh, Sharon Jia Hui, Traczyk, Anna, Prabhakar, Shyam, Stanton, Lawrence W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106647; http://hdl.handle.net/10220/25052
• Institution: Nanyang Technological University

Several transcription factors (TFs) have been implicated in neuroectoderm (NE) development, and recently, the TF PAX6 was shown to be critical for human NE specification. However, microRNA networks regulating human NE development have been poorly documented. We hypothesized that microRNAs activated...