MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression

• Main Authors: Neo, Wen Hao, Yap, Karen, Lee, Suet Hoay, Looi, Liang Sheng, Khandelia, Piyush, Neo, Sheng Xiong, Makeyev, Eugene V., Su, I-hsin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/106735; http://hdl.handle.net/10220/25120
• Institution: Nanyang Technological University

Polycomb group protein Ezh2 is a histone H3 Lys-27 histone methyltransferase orchestrating an extensive epigenetic regulatory program. Several nervous system-specific genes are known to be repressed by Ezh2 in stem cells and derepressed during neuronal differentiation. However, the molecular mechani...