Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria

• Main Authors: Panda, Saswati, Zhang, Jing, Tan, Nguan Soon, Ho, Bow, Ding, Jeak Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/106749; http://hdl.handle.net/10220/25030
• Institution: Nanyang Technological University

For nearly five decades since its discovery, the role of natural IgG, which pre‐exists in neonates and uninfected individuals, has remained unclear due to the general perception that natural antibodies lack affinity for pathogens. Here, we show for the first time that natural IgG recognizes a spectr...