A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming

• Main Authors: Su, I-hsin, Chan, Yun-Shen, Göke, Jonathan, Lu, Xinyi, Venkatesan, Nandini, Feng, Bo, Ng, Huck-Hui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106858; http://hdl.handle.net/10220/17982; http://dx.doi.org/10.1002/stem.1307
• Institution: Nanyang Technological University

PRDM14 is an important determinant of the human embryonic stem cell (ESC) identity and works in concert with the core ESC regulators to activate pluripotency-associated genes. PRDM14 has been previously reported to exhibit repressive activity in mouse ESCs and primordial germ cells; and while PRDM14...