SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells

• المؤلفون الرئيسيون: Lu, Xinyi, Göke, Jonathan, Sachs, Friedrich, Jacques, Pierre-Étienne, Liang, Hongqing, Feng, Bo, Bourque, Guillaume, Bubulya, Paula A., Ng, Huck-Hui
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Embryonic stem cells; RNA splicing
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82148; http://hdl.handle.net/10220/41098
• المؤسسة: Nanyang Technological University

Human embryonic stem cells (hESCs) harbour the ability to undergo lineage-specific differentiation into clinically relevant cell types. Transcription factors and epigenetic modifiers are known to play important roles in the maintenance of pluripotency of hESCs. However, little is known about regulat...