Correlative light and electron microscopy of telomeric repeat-binding factor 1 in mammalian cells

• Main Author: von Otter, Eric
• Other Authors: Sara Sandin
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences::Biophysics; Science::Chemistry::Crystallography::Electron microscopy
• Online Access: https://hdl.handle.net/10356/106933; http://hdl.handle.net/10220/50047
• Institution: Nanyang Technological University

Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes. Telomeric chromatin consists of ‘TTAGGG’ DNA repeats sequences, nucleosomes and specific telomere-binding proteins called “shelterin”. Shelterin is a six-protein complex that is essential for genome stability....