Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin

• Main Authors: Manimekalai, Malathy Sony Subramanian, Grüber, Ardina, Joon, Shin, Matsui, Tsutomu, Weiss, Thomas M., Grüber, Gerhard, Pan, Ankita, Saw, Wuan Geok
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Dengue; Flavivirus; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106990; http://hdl.handle.net/10220/49385
• Institution: Nanyang Technological University

Dengue virus (DENV), which has four serotypes (DENV‐1 to DENV‐4), is the causative agent of the viral infection dengue. DENV nonstructural protein 3 (NS3) comprises a serine protease domain and an RNA helicase domain which has nucleotide triphosphatase activities that are essential for RNA replicati...