Aminomethylation of enals through carbene and acid cooperative catalysis : concise access to β2-amino acids

• Main Authors: Chi, Robin Yonggui, Xu, Jianfeng, Chen, Xingkuan, Wang, Ming, Zheng, Pengcheng, Song, Bao-An
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Physical chemistry::Catalysis
• Online Access: https://hdl.handle.net/10356/107124; http://hdl.handle.net/10220/25281; http://dx.doi.org/10.1002/anie.201412132
• Institution: Nanyang Technological University

A convergent, organocatalytic asymmetric aminomethylation of α,β-unsaturated aldehydes by N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperative catalysis is disclosed. The catalytically generated conjugated acid from the base plays dual roles in promoting the formation of az...