Identification and characterization of an eIF4e DNA aptamer that inhibits proliferation with high throughput sequencing

• Main Authors: Guo, Wei Mei, Kong, Kiat Whye, Brown, Christopher John, Quah, Soo Tng, Yeo, Hui Ling, Hoon, Shawn, Seow, Yiqi
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/107320; http://hdl.handle.net/10220/25386
• Institution: Nanyang Technological University

Development of DNA aptamer screens that are both simple and informative can increase the success rate of DNA aptamer selection and induce greater adoption. High eIF4e levels contribute to malignancies, thus eIF4e presents itself as a valuable target for DNA aptamer-based inhibition screen. Here, we...