Improved eIF4E binding peptides by phage display guided design : plasticity of interacting surfaces yield collective effects

Eukaryotic initiation factor (eIF)4E is over-expressed in many types of cancer such as breast, head and neck, and lung. A consequence of increased levels of eIF4E is the preferential translation of pro-tumorigenic proteins (e.g. c-Myc and vascular endothelial growth factor) and as a result is regard...

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Bibliographic Details
Main Authors: Zhou, Weizhuang., Verma, Chandra Shekhar., Liu, Yun., Lane, David P., Brown, Christopher J., Tng, Quah Soo.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/95361
http://hdl.handle.net/10220/9217
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Institution: Nanyang Technological University
Language: English