Improved eIF4E binding peptides by phage display guided design : plasticity of interacting surfaces yield collective effects

• Main Authors: Zhou, Weizhuang., Verma, Chandra Shekhar., Liu, Yun., Lane, David P., Brown, Christopher J., Tng, Quah Soo.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/95361; http://hdl.handle.net/10220/9217
• Institution: Nanyang Technological University

Eukaryotic initiation factor (eIF)4E is over-expressed in many types of cancer such as breast, head and neck, and lung. A consequence of increased levels of eIF4E is the preferential translation of pro-tumorigenic proteins (e.g. c-Myc and vascular endothelial growth factor) and as a result is regard...