A digital micro magnetofluidic platform for lab-on-a-chip applications

This paper reports the design and investigation of a digital micro magnetofluidic platform for lab-on-a-chip applications. The platform allows a ferrofluid droplet to be driven along a preprogrammed path. The platform consists of a programmable x-y-positioning stage, a permanent magnet and a glass p...

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Bibliographic Details
Main Authors: Koh, Wei Hang, Lok, Khoi Seng, Nguyen, Nam-Trung
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/107348
http://hdl.handle.net/10220/16658
http://dx.doi.org/10.1115/1.4023443
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Institution: Nanyang Technological University
Language: English
Description
Summary:This paper reports the design and investigation of a digital micro magnetofluidic platform for lab-on-a-chip applications. The platform allows a ferrofluid droplet to be driven along a preprogrammed path. The platform consists of a programmable x-y-positioning stage, a permanent magnet and a glass plate coated with a thin layer of Teflon. First, the actuation of a stand-alone water-based ferrofluid droplet was investigated. Circular, rectangular, triangular and number-eight-shape trajectories were tested and analyzed. The speed of the droplet is evaluated from the position data of the black ferrofluid using a customized MATLAB program. The results show that better positioning accuracy and steady movement can be achieved with smooth trajectories. Next, the ferrofluid droplet as the driving engine for a cargo of other diamagnetic liquid droplets is demonstrated. The characteristics of different cargo volumes are investigated. Due to the liquid/liquid cohesion, a large cargo of five times the volume of a 3-μL ferrofluid droplet can be transported. If the cargo is larger than the driving ferrofluid droplet, the liquid system forms a long trail that faithfully follows the preprogrammed path. Various mixing experiments were carried out. The effectiveness of mixing in this system is demonstrated with a titration test as well as a chemiluminescence assay. The platform shows a robust, simple and flexible concept for implementing a complex analysis protocol with multiple reaction steps.