A digital micro magnetofluidic platform for lab-on-a-chip applications

This paper reports the design and investigation of a digital micro magnetofluidic platform for lab-on-a-chip applications. The platform allows a ferrofluid droplet to be driven along a preprogrammed path. The platform consists of a programmable x-y-positioning stage, a permanent magnet and a glass p...

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Main Authors: Koh, Wei Hang, Lok, Khoi Seng, Nguyen, Nam-Trung
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/107348
http://hdl.handle.net/10220/16658
http://dx.doi.org/10.1115/1.4023443
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1073482019-12-06T22:29:10Z A digital micro magnetofluidic platform for lab-on-a-chip applications Koh, Wei Hang Lok, Khoi Seng Nguyen, Nam-Trung School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering::Fluid mechanics This paper reports the design and investigation of a digital micro magnetofluidic platform for lab-on-a-chip applications. The platform allows a ferrofluid droplet to be driven along a preprogrammed path. The platform consists of a programmable x-y-positioning stage, a permanent magnet and a glass plate coated with a thin layer of Teflon. First, the actuation of a stand-alone water-based ferrofluid droplet was investigated. Circular, rectangular, triangular and number-eight-shape trajectories were tested and analyzed. The speed of the droplet is evaluated from the position data of the black ferrofluid using a customized MATLAB program. The results show that better positioning accuracy and steady movement can be achieved with smooth trajectories. Next, the ferrofluid droplet as the driving engine for a cargo of other diamagnetic liquid droplets is demonstrated. The characteristics of different cargo volumes are investigated. Due to the liquid/liquid cohesion, a large cargo of five times the volume of a 3-μL ferrofluid droplet can be transported. If the cargo is larger than the driving ferrofluid droplet, the liquid system forms a long trail that faithfully follows the preprogrammed path. Various mixing experiments were carried out. The effectiveness of mixing in this system is demonstrated with a titration test as well as a chemiluminescence assay. The platform shows a robust, simple and flexible concept for implementing a complex analysis protocol with multiple reaction steps. 2013-10-21T07:01:58Z 2019-12-06T22:29:10Z 2013-10-21T07:01:58Z 2019-12-06T22:29:10Z 2013 2013 Journal Article Koh, W. H., Lok, K. S., & Nguyen, N.-T. (2013). A digital micro magnetofluidic platform for lab-on-a-chip applications. Journal of Fluids Engineering, 135(2), 021302. 0098-2202 https://hdl.handle.net/10356/107348 http://hdl.handle.net/10220/16658 http://dx.doi.org/10.1115/1.4023443 en Journal of Fluids Engineering
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Mechanical engineering::Fluid mechanics
spellingShingle DRNTU::Engineering::Mechanical engineering::Fluid mechanics
Koh, Wei Hang
Lok, Khoi Seng
Nguyen, Nam-Trung
A digital micro magnetofluidic platform for lab-on-a-chip applications
description This paper reports the design and investigation of a digital micro magnetofluidic platform for lab-on-a-chip applications. The platform allows a ferrofluid droplet to be driven along a preprogrammed path. The platform consists of a programmable x-y-positioning stage, a permanent magnet and a glass plate coated with a thin layer of Teflon. First, the actuation of a stand-alone water-based ferrofluid droplet was investigated. Circular, rectangular, triangular and number-eight-shape trajectories were tested and analyzed. The speed of the droplet is evaluated from the position data of the black ferrofluid using a customized MATLAB program. The results show that better positioning accuracy and steady movement can be achieved with smooth trajectories. Next, the ferrofluid droplet as the driving engine for a cargo of other diamagnetic liquid droplets is demonstrated. The characteristics of different cargo volumes are investigated. Due to the liquid/liquid cohesion, a large cargo of five times the volume of a 3-μL ferrofluid droplet can be transported. If the cargo is larger than the driving ferrofluid droplet, the liquid system forms a long trail that faithfully follows the preprogrammed path. Various mixing experiments were carried out. The effectiveness of mixing in this system is demonstrated with a titration test as well as a chemiluminescence assay. The platform shows a robust, simple and flexible concept for implementing a complex analysis protocol with multiple reaction steps.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Koh, Wei Hang
Lok, Khoi Seng
Nguyen, Nam-Trung
format Article
author Koh, Wei Hang
Lok, Khoi Seng
Nguyen, Nam-Trung
author_sort Koh, Wei Hang
title A digital micro magnetofluidic platform for lab-on-a-chip applications
title_short A digital micro magnetofluidic platform for lab-on-a-chip applications
title_full A digital micro magnetofluidic platform for lab-on-a-chip applications
title_fullStr A digital micro magnetofluidic platform for lab-on-a-chip applications
title_full_unstemmed A digital micro magnetofluidic platform for lab-on-a-chip applications
title_sort digital micro magnetofluidic platform for lab-on-a-chip applications
publishDate 2013
url https://hdl.handle.net/10356/107348
http://hdl.handle.net/10220/16658
http://dx.doi.org/10.1115/1.4023443
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