Developing amyloid-β chaperone lipocalin-type prostaglandin D synthase protein as a magnetic resonance active early diagnostic tool

• Main Author: Sharma, Bhargy
• Other Authors: Konstantin Pervushin
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences::Biophysics
• Online Access: https://hdl.handle.net/10356/136881
• Institution: Nanyang Technological University

Lipocalin-type prostaglandin D synthase (L-PGDS) is an endogenous brain protein, shown previously as a significant chaperone for amyloid β (Aβ) peptide. It binds to monomeric Aβ as well as mature fibrils and is capable of inhibiting their aggregation. We recently showed that L-PGDS could successfull...