Multilayered siRNA nanoparticles as a delivery system for extended gene silencing effect

• Main Author: Ng, Alice Jie Ying
• Other Authors: Subbu S. Venkatraman
• Format: Thesis-Master by Research
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Engineering::Materials::Biomaterials; Engineering::Materials::Material testing and characterization
• Online Access: https://hdl.handle.net/10356/137141
• Institution: Nanyang Technological University

At present, various diseases occur without an effective mode of treatment. The production of undesirable proteins leads to the onset of many diseases. For instance, an elevated expression of secreted protein acidic and rich in cysteine (SPARC) is linked with fibrosis and the inhibition of SPARC expr...