Layer-by-layer nanoparticles as an efficient siRNA delivery vehicle for SPARC silencing

• Main Authors: Tan, Yang Fei, Chen, Min Hui Averil, Lessig, Jacqueline, Neu, Björn, Mundargi, Raghavendra C., Venkatraman, Subbu S., Wong, Tina T.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials::Nanostructured materials
• Online Access: https://hdl.handle.net/10356/103586; http://hdl.handle.net/10220/19326
• Institution: Nanyang Technological University

Efficient and safe delivery systems for siRNA therapeutics remain a challenge. Elevated secreted protein, acidic, and rich in cysteine (SPARC) protein expression is associated with tissue scarring and fibrosis. Here we investigate the feasibility of encapsulating SPARC-siRNA in the bilayers of layer...