An intact IRE1 transmembrane domain is necessary for UPR activation upon lipid bilayer stress in S. cerevisiae
Membrane integrity at the endoplasmic reticulum (ER) is compromised in metabolic diseases. Recently, it became evident that such ER lipid aberrations activate the unfolded protein response (UPRLBS). Using a truncated form of the UPR sensor Ire1 that is responsive solely to changes in lipid bilayer c...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/137434 |
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| Institution: | Nanyang Technological University |
| Language: | English |