Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised, we identified pathwa...

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Bibliographic Details
Main Authors: Ho, Nurulain, Yap, Wei Sheng, Xu, Jiaming, Wu, Haoxi, Koh, Jhee Hong, Goh, Wilson Wen Bin, George, Bhawana, Chong, Shu Chen, Taubert, Stefan, Thibault, Guillaume
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Genetics
Membrane and Lipid Biology
Online Access:https://hdl.handle.net/10356/149106
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/149106

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