Why breast cancer signatures are no better than random signatures explained
Random signature superiority (RSS) occurs when random gene signatures outperform published and/or known signatures. Unlike reproducibility and generalizability issues, RSS is relatively underexplored. Yet, understanding it is imperative for better analytical outcome. In breast cancer, RSS correlates...
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sg-ntu-dr.10356-1375442023-02-28T17:06:34Z Why breast cancer signatures are no better than random signatures explained Goh, Wilson Wen Bin Wong, Limsoon School of Biological Sciences Science::Biological sciences Bioinformatics Statistics Random signature superiority (RSS) occurs when random gene signatures outperform published and/or known signatures. Unlike reproducibility and generalizability issues, RSS is relatively underexplored. Yet, understanding it is imperative for better analytical outcome. In breast cancer, RSS correlates strongly with enrichment for proliferation genes and signature size. Removal of proliferation genes from random signatures reduces the predictive power of random signatures. Almost all genes are correlated to a certain extent with the proliferation signature, making complete elimination of its confounding effects impossible. RSS goes beyond breast cancer, because it also exists in other diseases; it is especially strong in other cancers in a platform-independent manner, and less severe, but present nonetheless, in nonproliferative diseases. Accepted version 2020-04-01T05:01:04Z 2020-04-01T05:01:04Z 2018 Journal Article Goh, W. W. B., & Wong, L. (2018). Why breast cancer signatures are no better than random signatures explained. Drug Discovery Today, 23(11), 1818-1823. doi:10.1016/j.drudis.2018.05.036 1359-6446 https://hdl.handle.net/10356/137544 10.1016/j.drudis.2018.05.036 29864526 2-s2.0-85048445981 11 23 1818 1823 en Drug Discovery Today © 2018 Elsevier Ltd. All rights reserved. This paper was published in Drug Discovery Today and is made available with permission of Elsevier Ltd. application/pdf |
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Science::Biological sciences Bioinformatics Statistics Goh, Wilson Wen Bin Wong, Limsoon Why breast cancer signatures are no better than random signatures explained |
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Random signature superiority (RSS) occurs when random gene signatures outperform published and/or known signatures. Unlike reproducibility and generalizability issues, RSS is relatively underexplored. Yet, understanding it is imperative for better analytical outcome. In breast cancer, RSS correlates strongly with enrichment for proliferation genes and signature size. Removal of proliferation genes from random signatures reduces the predictive power of random signatures. Almost all genes are correlated to a certain extent with the proliferation signature, making complete elimination of its confounding effects impossible. RSS goes beyond breast cancer, because it also exists in other diseases; it is especially strong in other cancers in a platform-independent manner, and less severe, but present nonetheless, in nonproliferative diseases. |
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School of Biological Sciences Goh, Wilson Wen Bin Wong, Limsoon |
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Goh, Wilson Wen Bin Wong, Limsoon |
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Goh, Wilson Wen Bin |
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Why breast cancer signatures are no better than random signatures explained |
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Why breast cancer signatures are no better than random signatures explained |
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Why breast cancer signatures are no better than random signatures explained |
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Why breast cancer signatures are no better than random signatures explained |
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Why breast cancer signatures are no better than random signatures explained |
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why breast cancer signatures are no better than random signatures explained |
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2020 |
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