PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy

• Main Authors: Wang, Liming, Cho, Yik-Lam, Tang, Yancheng, Wang, Jigang, Park, Jung-Eun, Wu, Yajun, Wang, Chunxin, Tong, Yan, Chawla, Ritu, Zhang, Jianbin, Shi, Yin, Deng, Shuo, Lu, Guang, Wu, Yihua, Tan, Hayden Weng-Siong, Pawijit, Pornteera, Lim, Grace Gui-Yin, Chan, Hui-Ying, Zhang, Jingzi, Fang, Lei, Yu, Hanry, Liou, Yih-Cherng, Karthik, Mallilankaraman, Bay, Boon-Huat, Lim, Kah-Leong, Sze, Siu-Kwan, Yap, Celestial T., Shen, Han-Ming
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; PTEN-L; Neurodegenerative Disorders
• Online Access: https://hdl.handle.net/10356/137546
• Institution: Nanyang Technological University

Mitophagy is an important type of selective autophagy for specific elimination of damaged mitochondria. PTEN-induced putative kinase protein 1 (PINK1)-catalyzed phosphorylation of ubiquitin (Ub) plays a critical role in the onset of PINK1-Parkin-mediated mitophagy. Phosphatase and tensin homolog (PT...