A hypoxia-responsive albumin-based nanosystem for deep tumor penetration and excellent therapeutic efficacy

• Main Authors: Yang, Guangbao, Phua, Fiona Soo Zeng, Lim, Wei Qi, Zhang, Rui, Feng, Liangzhu, Liu, Guofeng, Wu, Hongwei, Bindra, Anivind Kaur, Jana, Deblin, Liu, Zhuang, Zhao, Yanli
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Nanomedicine; Hypoxia
• Online Access: https://hdl.handle.net/10356/137689
• Institution: Nanyang Technological University

Uncontrolled cancer cell proliferation, insufficient blood flow, and inadequate endogenous oxygen lead to hypoxia in tumor tissues. Herein, a unique type of hypoxia-responsive human serum albumin (HSA)-based nanosystem (HCHOA) is reported, prepared by cross-linking the hypoxia-sensitive azobenzene g...