Regioselective copper-catalyzed oxidative coupling of α-alkylated styrenes with tertiary alkyl radicals

• Main Authors: Wang, Cong, Liu, Rui-Hua, Tian, Ming-Qing, Hu, Xu-Hong, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Oxidative Coupling; Radical
• Online Access: https://hdl.handle.net/10356/138243
• Institution: Nanyang Technological University

A radical-mediated oxidative cross-coupling of readily accessible α-alkylated styrenes with 1,3-dicarbonyl compounds utilizing a combination of Cu(OAc)2 and air as a catalytic system is described. Rather than requiring α-halocarbonyl compounds, this efficient approach enables direct installation of...