Direct activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysis

• Main Authors: Liu, Bin, Wang, Weihong, Huang, Ruoyan, Yan, Jiekuan, Wu, Jichang, Xue, Wei, Yang, Song, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry; NHC Catalyst; Carboxylic Esters
• Online Access: https://hdl.handle.net/10356/138257
• Institution: Nanyang Technological University

An N-heterocyclic carbene-catalyzed oxidative LUMO activation of the β-cabons of saturated carboxylic esters is disclosed. This approach allows for efficient asymmetric access to lactams and lactones by directly installing functional groups to the typically inert β-sp3 carbons of saturated esters. T...