Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization

Through the incorporation of a silicon atom to an aryl carboxylic ester substrate, the resulting C-Si bond can be activated via the addition of a carbene catalyst on a remote site. This strategy allows for efficient functionalization of the benzylic sp3-carbons of aryl carboxylic esters.

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Main Authors:	Wang, Hongling, Chen, Xingkuan, Li, Yongjia, Wang, Jilan, Wu, Shuquan, Xue, Wei, Yang, Song, Chi, Robin Yonggui
Other Authors:	School of Physical and Mathematical Sciences
Format:	Article
Language:	English
Published:	2020
Subjects:	Science::Chemistry::Organic chemistry
Online Access:	https://hdl.handle.net/10356/138275
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Institution:	Nanyang Technological University
Language:	English

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spelling	sg-ntu-dr.10356-1382752023-02-28T19:25:55Z Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization Wang, Hongling Chen, Xingkuan Li, Yongjia Wang, Jilan Wu, Shuquan Xue, Wei Yang, Song Chi, Robin Yonggui School of Physical and Mathematical Sciences Science::Chemistry::Organic chemistry Through the incorporation of a silicon atom to an aryl carboxylic ester substrate, the resulting C-Si bond can be activated via the addition of a carbene catalyst on a remote site. This strategy allows for efficient functionalization of the benzylic sp3-carbons of aryl carboxylic esters. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Accepted version 2020-04-30T02:41:05Z 2020-04-30T02:41:05Z 2018 Journal Article Wang, H., Chen, X., Li, Y., Wang, J., Wu, S., Xue, W., . . ., Chi, R. Y. (2017). Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization. Organic letters, 20(2), 333-336. doi:10.1021/acs.orglett.7b03544 1523-7060 https://hdl.handle.net/10356/138275 10.1021/acs.orglett.7b03544 29286252 2-s2.0-85040820257 2 20 333 336 en Organic letters © 2017 American Chemical Society. All rights reserved. This paper was published in Organic letters and is made available with permission of American Chemical Society. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Science::Chemistry::Organic chemistry
spellingShingle	Science::Chemistry::Organic chemistry Wang, Hongling Chen, Xingkuan Li, Yongjia Wang, Jilan Wu, Shuquan Xue, Wei Yang, Song Chi, Robin Yonggui Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization
description	Through the incorporation of a silicon atom to an aryl carboxylic ester substrate, the resulting C-Si bond can be activated via the addition of a carbene catalyst on a remote site. This strategy allows for efficient functionalization of the benzylic sp3-carbons of aryl carboxylic esters.
author2	School of Physical and Mathematical Sciences
author_facet	School of Physical and Mathematical Sciences Wang, Hongling Chen, Xingkuan Li, Yongjia Wang, Jilan Wu, Shuquan Xue, Wei Yang, Song Chi, Robin Yonggui
format	Article
author	Wang, Hongling Chen, Xingkuan Li, Yongjia Wang, Jilan Wu, Shuquan Xue, Wei Yang, Song Chi, Robin Yonggui
author_sort	Wang, Hongling
title	Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization
title_short	Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization
title_full	Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization
title_fullStr	Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization
title_full_unstemmed	Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization
title_sort	addition of n-heterocyclic carbene catalyst to aryl esters induces remote c-si bond activation and benzylic carbon functionalization
publishDate	2020
url	https://hdl.handle.net/10356/138275
_version_	1759857302588882944

Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization

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