Addition of N-heterocyclic carbene catalyst to aryl esters induces remote C-Si bond activation and benzylic carbon functionalization

• Main Authors: Wang, Hongling, Chen, Xingkuan, Li, Yongjia, Wang, Jilan, Wu, Shuquan, Xue, Wei, Yang, Song, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/138275
• Institution: Nanyang Technological University

Through the incorporation of a silicon atom to an aryl carboxylic ester substrate, the resulting C-Si bond can be activated via the addition of a carbene catalyst on a remote site. This strategy allows for efficient functionalization of the benzylic sp3-carbons of aryl carboxylic esters.