Carbene-catalyzed [4 + 2] cycloadditions of vinyl enolate and (in situ generated) imines for enantioselective synthesis of quaternary α-amino phosphonates

• المؤلفون الرئيسيون: Sun, Jun, Mou, Chengli, Wang, Zhongyao, He, Fangcheng, Wu, Jian, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Chemistry::Organic chemistry; Carbene-catalyzed; Enantioselective
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/138289

A carbene-catalyzed enantioselective addition of enals to five-membered cyclic imines is developed. The reaction gives chiral quaternary α-amino phosphonates bearing tetrasubstituted carbon centers with excellent enantioselectivities. The imine substrates can be generated in situ from the correspond...