Carbene-catalyzed [4 + 2] cycloadditions of vinyl enolate and (in situ generated) imines for enantioselective synthesis of quaternary α-amino phosphonates
A carbene-catalyzed enantioselective addition of enals to five-membered cyclic imines is developed. The reaction gives chiral quaternary α-amino phosphonates bearing tetrasubstituted carbon centers with excellent enantioselectivities. The imine substrates can be generated in situ from the correspond...
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| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/138289 |
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| Institution: | Nanyang Technological University |
| Language: | English |